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Capillary Electrophoresis Separation Of Neutral Organic Compounds, Pharmaceutical Drugs, Enantiomers And Anions

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Capillary Electrophoresis Separation Of Neutral Organic Compounds, Pharmaceutical Drugs, Enantiomers And Anions

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dc.contributor.author Feng, Qing en_US
dc.date.accessioned 2012-04-11T20:59:04Z
dc.date.available 2012-04-11T20:59:04Z
dc.date.issued 2012-04-11
dc.date.submitted January 2011 en_US
dc.identifier.other DISS-11369 en_US
dc.identifier.uri http://hdl.handle.net/10106/9628
dc.description.abstract The focus of this thesis is on using capillary electrophoresis (CE) with on-column UV detection in achiral and chiral separations. Chapter 1 provides a brief introduction to the principle, mechanism, meaning and application of the CE method. Chapter 2 presents the CE separation of multivalent anions by using di- and tetracationic ion pairing reagents. Two newly developed UV transparent phosphonium-based cationic reagents were evaluated as additivesto the background electrolyte of CE for the separation of multiply charged anions, including several complex anions. These cationic reagents showed moderate suppression of the electroosmotic flow (EOF), interacted with the analytes to improve their separation and often improved the peak shape. The effects of the additives and their concentration on the separation were studied, as well as the buffer type, pH and voltage. Chapter 3 examines the CE enantiomeric separation of sixteen 4,5-disubstituted imidazoles. Different cyclodextrin-based chiral selectors were used and the separation conditions were optimized. Meanwhile, comparisons of these results to HPLC separations were made. en_US
dc.description.sponsorship Armtrong, Daniel en_US
dc.language.iso en en_US
dc.publisher Chemistry & Biochemistry en_US
dc.title Capillary Electrophoresis Separation Of Neutral Organic Compounds, Pharmaceutical Drugs, Enantiomers And Anions en_US
dc.type M.S. en_US
dc.contributor.committeeChair Armtrong, Daniel en_US
dc.degree.department Chemistry & Biochemistry en_US
dc.degree.discipline Chemistry & Biochemistry en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US

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