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The Effect Of Morphine On Dopamine Neuron Activation In Males And Cycling Females

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The Effect Of Morphine On Dopamine Neuron Activation In Males And Cycling Females

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dc.contributor.author Eimerbrink, Micah en_US
dc.date.accessioned 2012-04-11T20:56:43Z
dc.date.available 2012-04-11T20:56:43Z
dc.date.issued 2012-04-11
dc.date.submitted January 2011 en_US
dc.identifier.other DISS-11494 en_US
dc.identifier.uri http://hdl.handle.net/10106/9592
dc.description.abstract The aim of this study was to evaluate the influence of estrogen on the electrophysiological response of ventral tegmental area (VTA) dopamine (DA) neurons to morphine (10 mg/kg; IP) in experimentally naïve adult male and intact adult female cycling Sprague-Dawley rats. Five groups were studied: males, proestrus females, estrus females, metestrus females, and diestrus females. Continuous 40 minute recordings were collected for each animal (5 minutes baseline, 5 minutes after a saline (0.9% NaCl) injection, and 30 minutes after morphing injection (10 mg/kg)). Results showed significant increases in VTA DA activity in the Metestrus and Male groups, no significant differences in activity in the Diestrus and Proestrus groups, and a significant decline in activity in the Estrus group after a morphine injection. Between group differences show that the Metestrus and Male group's DA activity significantly increased relative to the other groups at the corresponding time points. This study did not support the hypothesis that estrogen enhances VTA DA neuron activation following morphine administration. en_US
dc.description.sponsorship Peng, Yuan Bo en_US
dc.language.iso en en_US
dc.publisher Psychology en_US
dc.title The Effect Of Morphine On Dopamine Neuron Activation In Males And Cycling Females en_US
dc.type M.S. en_US
dc.contributor.committeeChair Peng, Yuan Bo en_US
dc.degree.department Psychology en_US
dc.degree.discipline Psychology en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US

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