RESEARCH COMMONS
LIBRARY

Gold/ Copper Sulphide And Gold Nanoparticles For Application In Cancer Therapy

ResearchCommons/Manakin Repository

Gold/ Copper Sulphide And Gold Nanoparticles For Application In Cancer Therapy

Show simple item record

dc.contributor.author Lakshmanan, Santana Bala en_US
dc.date.accessioned 2012-04-11T20:55:48Z
dc.date.available 2012-04-11T20:55:48Z
dc.date.issued 2012-04-11
dc.date.submitted January 2011 en_US
dc.identifier.other DISS-11460 en_US
dc.identifier.uri http://hdl.handle.net/10106/9563
dc.description.abstract The main goal of this research is to use Gold/ Copper Sulphide (Au/ CuS) and Gold nanoparticles (AuNPs) for improving the therapeutic effects in the treatment of cancer. One of the biggest successes in photothermal therapy is the use of AuNPs which however has its own drawbacks i.e. it is expensive and that the NIR absorption of Au nanostructures is from surface plasmon resonance which is dependent on the dielectric constant of the surrounding matrix. Thus, the plasmon absorption maxima would shift for in-vivo observations compared to in-vitro. Alternatively, Copper Sulphide (CuS) nanoparticles, developed recently, have also been used for photothermal therapy. CuS nanoparticles are much cheaper than AuNPs, they have NIR absorptions around 900 nm which originates from the d-d transition of Cu 2+ ions and hence it is not sensitive to size, shape or solvents, but their photothermal conversion efficiency is much lower than that of Au. Therefore, in this work, we combined the above two nanoparticle systems and developed a new type of agent - Au/ CuS core/shell nanoparticles that have better photothermal conversion efficiency and also overcome the limitations of the existing nanoparticle systems for photothermal therapy. TEM, EDS and UV-Vis-NIR results confirmed the CuS coating on AuNPs. From UV-Vis-NIR spectroscopy we obtained that these core/shell nanoparticles have their maximum absorbance at 981 nm in the NIR region thus making them suitable for in vivo applications. Their absorption intensity was much higher than only Au and only CuS nanoparticles systems which in turn is responsible for their relatively high photothermal conversion efficiency. These core/ shell nanoparticles are also non-toxic and biocompatible and hence could be used for cell studies. Fluorescence properties of these Au/ CuS nanoparticles are an added advantage during photothermal treatment. They serve as fluorescent imaging agents for cancer cells and help in confirming the cellular uptake of nanoparticles. Photothermal studies proved the high photothermal conversion efficiency of Au/ CuS nanoparticles at laser powers much lower than the safety limit for human skin exposure. Recently, AuNPs have also been studied as a radiation dose enhancement agent. Therefore, in our research we also investigated the AuNPs as a radiosensitizer in an orthotopic human prostate cancer rat model. As the first step towards this goal, preliminary studies were carried out at the in vitro level with AuNPs for radiation enhancement in three different cancer cell lines. AuNPs of an optimum size of 50 nm were synthesized and characterized. All the three cell lines showed different radiation enhancement effects upon irradiation with AuNPs and radiation enhancement was observed especially at lower doses. en_US
dc.description.sponsorship Chen, Wei en_US
dc.language.iso en en_US
dc.publisher Materials Science & Engineering en_US
dc.title Gold/ Copper Sulphide And Gold Nanoparticles For Application In Cancer Therapy en_US
dc.type M.S. en_US
dc.contributor.committeeChair Chen, Wei en_US
dc.degree.department Materials Science & Engineering en_US
dc.degree.discipline Materials Science & Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US

Files in this item

Files Size Format View
Lakshmanan_uta_2502M_11460.pdf 4.426Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Browse

My Account

Statistics

About Us