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Ralbp1 In Stress Resistance

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Ralbp1 In Stress Resistance

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dc.contributor.author Drake, Kenneth en_US
dc.date.accessioned 2008-08-08T02:31:05Z
dc.date.available 2008-08-08T02:31:05Z
dc.date.issued 2008-08-08T02:31:05Z
dc.date.submitted December 2007 en_US
dc.identifier.other DISS-1996 en_US
dc.identifier.uri http://hdl.handle.net/10106/912
dc.description.abstract Ralbp1 is a multi-specific transporter of glutathione conjugates as well as unconjugated amphiphilic toxins. Because glutathione conjugates are major metabolites of toxic lipid peroxidation products generated as a consequence of oxidant and radiant stress, the hypothesis is put forth that the function of Ralbp1 in-vivo and in vitro should be to protect organisms from chemical stress by removing toxic chemicals. Studies described in this dissertation were designed to prove this hypothesis. We tested the hypothesis by examining whether the inhibition or augmentation of Ralbp1 would sensitize or protect cells and whole animals from the toxic effects of chemicals and radiation. These studies establish that Ralbp1 is a primary determinant of resistance to chemical stressors by the direct transport of these toxins. en_US
dc.description.sponsorship Awasthi, Sanjay en_US
dc.language.iso EN en_US
dc.publisher Chemistry & Biochemistry en_US
dc.title Ralbp1 In Stress Resistance en_US
dc.type Ph.D. en_US
dc.contributor.committeeChair Awasthi, Sanjay en_US
dc.degree.department Chemistry & Biochemistry en_US
dc.degree.discipline Chemistry & Biochemistry en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level doctoral en_US
dc.degree.name Ph.D. en_US

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