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Ral Interacting Protein (Ralbp1): Linking Glutathione Conjugate Transport To Oxidative Stress Defenses And Signaling Pathways

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Ral Interacting Protein (Ralbp1): Linking Glutathione Conjugate Transport To Oxidative Stress Defenses And Signaling Pathways

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dc.contributor.author Wickramarachchi, Dilki en_US
dc.date.accessioned 2008-08-08T02:31:05Z
dc.date.available 2008-08-08T02:31:05Z
dc.date.issued 2008-08-08T02:31:05Z
dc.date.submitted December 2007 en_US
dc.identifier.other DISS-1995 en_US
dc.identifier.uri http://hdl.handle.net/10106/911
dc.description.abstract The glutathione-conjugate transporter protein DNP-SG ATPase was demonstrated to be identical to the independently cloned Ral-effector, Ralbp1. Glutathione-conjugate transport is linked to substrate-stimulated ATPase activity, while GTPase stimulating activity (GAP-activity), and clathrin-coated pit-binding activity was demonstrated for this protein by different groups of investigators. The relationship between these activities and physiological functions of Ralbp1 were not clear. The present studies were designed to address the hypothesis that the ability of Ralbp1 to couple the hydrolysis of ATP with the movement of substances, i.e. its transport activity, is the crucial element that allows Ralbp1 to function as a stress-defense protein. Results of these studies, demonstrating 1) the requirement of Ralbp1 for PKC alpha mediated resistance-signaling, 2) the identification of transmembrane spanning domains of Ralbp1 and requirement of membrane anchorage for transport function, and 3) the requirement of transport function for clathrin-dependent ligand-receptor endocytosis to occur, offer strong evidence in support of this proposal. en_US
dc.description.sponsorship Awasthi, Sanjay en_US
dc.language.iso EN en_US
dc.publisher Chemistry & Biochemistry en_US
dc.title Ral Interacting Protein (Ralbp1): Linking Glutathione Conjugate Transport To Oxidative Stress Defenses And Signaling Pathways en_US
dc.type Ph.D. en_US
dc.contributor.committeeChair Awasthi, Sanjay en_US
dc.degree.department Chemistry & Biochemistry en_US
dc.degree.discipline Chemistry & Biochemistry en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level doctoral en_US
dc.degree.name Ph.D. en_US

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