Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer

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Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer

Show simple item record Jung, Junkyu en_US 2007-08-23T01:56:02Z 2007-08-23T01:56:02Z 2007-08-23T01:56:02Z December 2006 en_US
dc.identifier.other DISS-1598 en_US
dc.description.abstract Cryosurgery, which is to destroy tumors by use of localized freezing, is an emerging treatment modality for breast cancer as the size of detectable tumor becomes smaller due to more frequent use of various diagnostic imaging including MRI, CT and mammogram. Although general surgical guideline has been developed and its effectiveness has been demonstrated, cryosurgical protocol should be adjusted for a given patient to accommodate patient-specific variations including tumor size, location and geometry of patient's breast. In this study, a computerized treatment planning tool was developed to aid surgeons to determine surgical parameters considering patient specific diagnostic information. This tool consists of three modules - 1) three dimensional reconstruction of diagnostic images, 2) numerical simulation of cryosurgical procedure, and 3) prediction of the treatment outcome. Three dimensional image reconstruction was performed by digitizing two patient specific diagnostic images perpendicular to each other, importing the digitized key points of the images into a commercial finite element analysis software (ANSYS), and constructing three dimensional volume. With a given surgical parameter, the numerical simulation module performed three dimensional transient thermal analysis of a cryosurgical procedure. Using the results of thermal analysis, the extent of cryodesturction was predicted through an empirical correlation for cryoinjury of human breast cancer cells. By iteratively using the developed modules, the surgical parameters can be determined for optimum treatment outcome. en_US
dc.description.sponsorship Han, Bumsoo en_US
dc.language.iso EN en_US
dc.publisher Mechanical Engineering en_US
dc.title Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer en_US
dc.type M.S.M.E. en_US
dc.contributor.committeeChair Han, Bumsoo en_US Mechanical Engineering en_US Mechanical Engineering en_US University of Texas at Arlington en_US masters en_US M.S.M.E. en_US
dc.identifier.externalLinkDescription Link to Research Profiles

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