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Use Of Temperature Sensitive Mutants To Map Reovirus Induced Oncolysis

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Use Of Temperature Sensitive Mutants To Map Reovirus Induced Oncolysis

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dc.contributor.author Tam, Ka Ian en_US
dc.date.accessioned 2007-08-23T01:55:59Z
dc.date.available 2007-08-23T01:55:59Z
dc.date.issued 2007-08-23T01:55:59Z
dc.date.submitted August 2006 en_US
dc.identifier.other DISS-1449 en_US
dc.identifier.uri http://hdl.handle.net/10106/60
dc.description.abstract Reovirus is known to establish persistent infections in normal cells while selectively destroying transformed cells. Individual viruses from each of the ten groups of Reovirus temperature sensitive mutants were used to examine the gene or genes involved in the differential lysis activity. Ts mutants have one of the ten genes impaired when growing at the non-permissive temperature, while they behave like wild type when growing at the permissive temperature. Normal cells and their transformed cells counterpart were used in this study: L929, WI-38, WI-38 VA132RA, T1, N1, and MYC-3. Reovirus maintains a persistent infection in normal cell lines, but lyses the transformed cell lines. However, the tsE did not lyse the T1 and Myc3 cells while tsG did not lyse the Myc3 cells. The tsE and tsG have their gene lesion in S3 and S4 genes respectively, which demonstrated that σNS and σ3 are involved in the differential lysis activities. en_US
dc.description.sponsorship Roner, Michael en_US
dc.language.iso EN en_US
dc.publisher Biology en_US
dc.title Use Of Temperature Sensitive Mutants To Map Reovirus Induced Oncolysis en_US
dc.type M.S. en_US
dc.contributor.committeeChair Roner, Michael en_US
dc.degree.department Biology en_US
dc.degree.discipline Biology en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US
dc.identifier.externalLink https://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=36
dc.identifier.externalLinkDescription Link to Research Profiles

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