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Examining The Impact Of Opioid Withdrawal On Pain Processing: The Influence Of Social Isolation Stress

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Examining The Impact Of Opioid Withdrawal On Pain Processing: The Influence Of Social Isolation Stress

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dc.contributor.author Uhelski, Megan Lynne en_US
dc.date.accessioned 2011-07-14T20:54:07Z
dc.date.available 2011-07-14T20:54:07Z
dc.date.issued 2011-07-14
dc.date.submitted January 2011 en_US
dc.identifier.other DISS-11171 en_US
dc.identifier.uri http://hdl.handle.net/10106/5849
dc.description.abstract The use of opioids as a traditional treatment for acute and chronic pain has been severely hindered by the addictive nature of these substances and the pain relief they provide. Clinical reports suggest that opioid addicts are hypersensitive to pain during abstinence, and this effect may persist for months afterward. Examinations of nociceptive processing during opioid withdrawal in rodents have produced mixed results, with little evidence of decreased thresholds or latencies to noxious stimuli. To date, no studies have explicitly evaluated pain affect during the withdrawal period. Therefore, the purpose of the current study was evaluate both sensory and affective pain processing in response to opioid withdrawal as well as the impact of social isolation stress on these measures. Sensory pain processing was examined during the seven-day morphine dosing period and over a five day period following abstinence. Pain affect was evaluated during the withdrawal period, following the induction of an experimental inflammatory condition. The doses of morphine selected produced robust analgesia and a reliable withdrawal syndrome. The results demonstrated no changes in sensory pain processing in response to morphine or social isolation during the withdrawal period, but differential effects of morphine and social isolation on pain affect on the first and second days of withdrawal. Group-housed subjects in morphine withdrawal demonstrated increased pain affect relative to saline-dosed subjects, but only on the first day of testing. Socially isolated subjects demonstrated decreased pain affect in comparison to group-housed subjects on the first and second day only, and no difference between socially isolated morphine- and saline-dosed subjects were present. The current study provides evidence of altered emotional pain processing during withdrawal, which could contribute to the development of novel treatments for opioid addicts with underlying chronic pain conditions. en_US
dc.description.sponsorship Fuchs, Perry en_US
dc.language.iso en en_US
dc.publisher Psychology en_US
dc.title Examining The Impact Of Opioid Withdrawal On Pain Processing: The Influence Of Social Isolation Stress en_US
dc.type Ph.D. en_US
dc.contributor.committeeChair Fuchs, Perry en_US
dc.degree.department Psychology en_US
dc.degree.discipline Psychology en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level doctoral en_US
dc.degree.name Ph.D. en_US

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