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A Biochemical Approach To Determine The Target Site Recognition Mechanism Of The R2 Retrotransposable Elements

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A Biochemical Approach To Determine The Target Site Recognition Mechanism Of The R2 Retrotransposable Elements

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dc.contributor.author Thompson, Blaine K. en_US
dc.date.accessioned 2011-07-14T20:53:35Z
dc.date.available 2011-07-14T20:53:35Z
dc.date.issued 2011-07-14
dc.date.submitted January 2011 en_US
dc.identifier.other DISS-11166 en_US
dc.identifier.uri http://hdl.handle.net/10106/5818
dc.description.abstract Non-LTR Retrotransposons (NLRs) are selfish mobile genetic elements which parasitize the genomes of many organisms including humans. These elements transpose through an RNA intermediate and integrate directly into their genomic site using reverse transcription, a process called Target Primed Reverse Transcription (TPRT). Members of this family of transposons are abundant in the genomes of many eukaryotes including mammals, reptiles, fish, and insects. Several NLR family members such as R2 and NeSL-1 avoid causing deleterious mutations by specifically targeting repetitive genomic loci such as the 28S ribosomal DNA gene and the Spliced leader-1 exon respectively. This literature review focuses on the integration mechanism and evolution of NLRs, specifically R2. en_US
dc.description.sponsorship Christensen, Shawn en_US
dc.language.iso en en_US
dc.publisher Biology en_US
dc.title A Biochemical Approach To Determine The Target Site Recognition Mechanism Of The R2 Retrotransposable Elements en_US
dc.type M.S. en_US
dc.contributor.committeeChair Christensen, Shawn en_US
dc.degree.department Biology en_US
dc.degree.discipline Biology en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US

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