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Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity?

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Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity?

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dc.contributor.author Gatchel, Robert J.
dc.contributor.author Garofalo, John P.
dc.contributor.author Robinson, Richard C.
dc.date.accessioned 2010-08-11T19:17:02Z
dc.date.available 2010-08-11T19:17:02Z
dc.date.issued 2006-07
dc.identifier.citation Published in Journal of Applied Biobehavioral Research 11 (3-4) 176-178, 2006 en_US
dc.identifier.uri http://hdl.handle.net/10106/5011
dc.description Author's final draft after peer review, also known as a post print. en_US
dc.description.abstract Dysregulation of the hypothalamic–pituitary–adrenocortical (HPA) axis is believed to be a valid biological marker of stress. This study evaluating changes in patients with temporomandibular disorders (TMD) and low back pain (LBP) to determine whether dysregulation of this system represents a marker for chronicity. Salivary cortisol samples were collected from 78 patients (TMD = 41, LBP = 37) upon waking up and 20 minutes later daily for 2 weeks. High-risk patients for chronic pain had different overall cortisol levels versus lowrisk patients. High-risk patients exhibited greater variability in terms of cortisol secretion compared with low-risk patients, F (1, 1,243) = 17.73, p < .000. These results provide evidence of a neuroendocrine mechanism underlying a constellation of psychosocial risk factors for chronic pain. en_US
dc.description.sponsorship Supported in part by Grant Nos. 2RO1 DE10713, K05 MH01107 and 3RO1 MH46452 by the National Institutes of Health. en_US
dc.language.iso en_US en_US
dc.publisher Wiley-Blackwell en_US
dc.subject Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation en_US
dc.subject Chronic pain en_US
dc.subject Low back pain en_US
dc.subject HPA en_US
dc.title Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity? en_US
dc.type Article en_US
dc.publisher.department Department of Psychology, The University of Texas at Arlington en_US
dc.identifier.externalLink http://dx.doi.org/10.1111/j.1751-9861.2007.00003.x en_US
dc.identifier.externalLinkDescription The original publication is available at article DOI en_US

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