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Enhancement Of Cryoinjury By Use Of Eutectic Crystallization Of An Amino Acid Adjuvant

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Enhancement Of Cryoinjury By Use Of Eutectic Crystallization Of An Amino Acid Adjuvant

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dc.contributor.author Wang, Chuo-Li en_US
dc.date.accessioned 2007-08-23T01:56:41Z
dc.date.available 2007-08-23T01:56:41Z
dc.date.issued 2007-08-23T01:56:41Z
dc.date.submitted August 2006 en_US
dc.identifier.other DISS-1487 en_US
dc.identifier.uri http://hdl.handle.net/10106/411
dc.description.abstract Enhancement of cryoinjury by use of eutectic formation was investigated to improve the efficacy of cryosurgery. Although the enhancement of cryoinjury associated with eutectic crystallization of sodium chloride (NaCl) has been demonstrated, its advantage can be maximized with adjuvants which are biocompatible and have higher eutectic temperature than NaCl. In this study, the feasibility of glycine, which is less toxic and have higher eutectic temperature than NaCl, was tested. Two groups of MCF-7 human breast cancer cell were suspended in isotonic saline with glycine, then were frozen and thawed on a directional solidification stage in the same protocol except that eutectic crystallization was initiated in only one group. The results show that the post-thaw viability drops from 86% to 38.6% upon the initiation of eutectic crystallization at a high temperature (-8.5°C). The results also confirm that enhancement of direct cell injury during freezing can be achieved by eutectic crystallization. en_US
dc.description.sponsorship Han, Bumsoo en_US
dc.language.iso EN en_US
dc.publisher Mechanical Engineering en_US
dc.title Enhancement Of Cryoinjury By Use Of Eutectic Crystallization Of An Amino Acid Adjuvant en_US
dc.type M.S.M.E. en_US
dc.contributor.committeeChair Han, Bumsoo en_US
dc.degree.department Mechanical Engineering en_US
dc.degree.discipline Mechanical Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S.M.E. en_US
dc.identifier.externalLink https://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=245
dc.identifier.externalLinkDescription Link to Research Profiles

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