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Fabrication And Mechanical Characterization Of A Two-ply Cross Fiber Stent And Fibers Comprising Blends Of Poly(L-lactic Acid)

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Fabrication And Mechanical Characterization Of A Two-ply Cross Fiber Stent And Fibers Comprising Blends Of Poly(L-lactic Acid)

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dc.contributor.author Gampa, Sushma en_US
dc.date.accessioned 2007-08-23T01:56:24Z
dc.date.available 2007-08-23T01:56:24Z
dc.date.issued 2007-08-23T01:56:24Z
dc.date.submitted November 2005 en_US
dc.identifier.other DISS-1158 en_US
dc.identifier.uri http://hdl.handle.net/10106/277
dc.description.abstract Recent studies indicate that stabilization of vulnerable atherosclerotic plaques is critical for minimizing acute coronary syndromes. In this regard a new biodegradable stent design, the Two-ply cross fiber stent, has been developed to reduce stent-imposed stresses on such plaque and to provide increased drug reservoir capability. A comparative study of the mechanical properties of Two-ply and Single-ply stent designs was performed. Fibers comprising PLLA blends were developed and their thermal and mechanical properties were determined. Lateral spreading of helical fibers upon deployment of the Two ply design was observed that, in theory, may reduce stresses on the plaque surface. The results indicate that the 1.5 mm furled Two-ply cross fiber stent can be expanded fully, to 3.1 ± 0.1 mm diameter, with an inflation pressure of less than 5 atm. Use of two fiber plies increased the hoop strength without significantly affecting the longitudinal flexibility, thereby maintaining maneuverability whilst improving collapse resistance after deployment. Calorimetry measurements indicate that blends containing up to 50% of 100kD PLLA are suitable for incorporation of the anti-inflammatory drug Curcumin by melt extrusion. en_US
dc.description.sponsorship Eberhart, Robert en_US
dc.language.iso EN en_US
dc.publisher Biomedical Engineering en_US
dc.title Fabrication And Mechanical Characterization Of A Two-ply Cross Fiber Stent And Fibers Comprising Blends Of Poly(L-lactic Acid) en_US
dc.type M.S. en_US
dc.contributor.committeeChair Eberhart, Robert en_US
dc.degree.department Biomedical Engineering en_US
dc.degree.discipline Biomedical Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US
dc.identifier.externalLink https://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=163
dc.identifier.externalLinkDescription Link to Research Profiles

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