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A Geometric Inequality in Pharmacokinetics

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A Geometric Inequality in Pharmacokinetics

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Title: A Geometric Inequality in Pharmacokinetics
Author: Holyk, Jennifer; Ghandehari, Mostafa
Abstract: The arithmetic-geometric mean inequality is used to give a lower bound for the average concentration in a two-compartmental model in pharmacokinetics. A geometric interpretation is given to relate concentration to the area of a rectangle as a function of time. Generalization to multi-compartmental models is discussed. Formulas for a variable dosage regimen are derived using concepts from engineering economy and mathematics of finance.
URI: http://hdl.handle.net/10106/2355
Date: 2006-02

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