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Nannoscale Approaches For Biomolecule Separation And Detection

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Nannoscale Approaches For Biomolecule Separation And Detection

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dc.contributor.author Goyal, Swati en_US
dc.date.accessioned 2010-03-03T23:30:42Z
dc.date.available 2010-03-03T23:30:42Z
dc.date.issued 2010-03-03T23:30:42Z
dc.date.submitted January 2009 en_US
dc.identifier.other DISS-10498 en_US
dc.identifier.uri http://hdl.handle.net/10106/2058
dc.description.abstract Nanotechnology has the potential to contact and impact the biological interactions at the most basic chemical and physical levels. New approaches to nanodevices allow high sensitivity and specificity with low sample requirement. Such devices are potential candidates for early disease detection at molecular levels and have important implications in associated therapeutics.This research work focuses on two different areas: developing devices for DNA detection, protein enrichment and exploring material properties to fabricate microscale/nanoscale structures. In one approach, hairpin probe DNA was used to detect fmol of ss-DNA from k-ras oncogene. In another approach, nanochannel based device was developed to selectively increase the concentration of one protein from a mixture of proteins taking advantage of antigen-antibody interactions in nanochannels. The phenomenon was demonstrated with selective separation of BSA and human hemoglobin. Further, effect of fluorescence on fluid flow through channels was studied. Towards biocompatible membranes, a rapid, simple and inexpensive approach to fabricate microchannels from 100-700 micron was developed. These channels were made in PDMS using simple chemistry and materials like nanoparticles, polyurethane and acetone, at various curing temperatures. en_US
dc.description.sponsorship Iqbal, Samir en_US
dc.language.iso EN en_US
dc.publisher Biomedical Engineering en_US
dc.title Nannoscale Approaches For Biomolecule Separation And Detection en_US
dc.type M.S. en_US
dc.contributor.committeeChair Iqbal, Samir en_US
dc.degree.department Biomedical Engineering en_US
dc.degree.discipline Biomedical Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US
dc.identifier.externalLink https://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=1933
dc.identifier.externalLinkDescription Link to Research Profiles

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