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Examining The Effects Of Early Life Stress From Maternal Separation On Measures Of Pain And Anxiety

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Examining The Effects Of Early Life Stress From Maternal Separation On Measures Of Pain And Anxiety

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dc.contributor.author Uhelski, Megan Lynne en_US
dc.date.accessioned 2009-09-16T18:20:47Z
dc.date.available 2009-09-16T18:20:47Z
dc.date.issued 2009-09-16T18:20:47Z
dc.date.submitted January 2009 en_US
dc.identifier.other DISS-10181 en_US
dc.identifier.uri http://hdl.handle.net/10106/1906
dc.description.abstract Animal models of stress-induced conditions have provided important insight into the physiological mechanisms of many chronic disorders. Models of early life stress involve procedures designed to induce prenatal or postnatal stress upon pups, which produces adult rats with enhanced stress responses and behavioral similarities to animal models of schizophrenia, anxiety, and depression. Since little research has focused on the effect of maternal separation on adult pain processing, the purpose of the current study is to examine both sensory and affective pain measures in adult rats following repeated maternal separation in infancy, a common model of early life stress. Eighty-six male pups were utilized following either early maternal separation (EMS) or early handling (EH). Although sensory thresholds remained unaltered for adult EMS rats, their emotional response to nociceptive stimuli intensified under certain conditions. In addition, EMS rats demonstrated more hyperactivity and anxiety-like behavior in the elevated plus maze. This indicates that early life stress leads to exaggerated emotional responses to novel or nociceptive stimuli in adulthood. Further research could determine whether or not this pattern holds true for different pain models, or if post-weaning enrichment could reverse the effects of maternal separation on pain processing. en_US
dc.description.sponsorship Fuchs, Perry en_US
dc.language.iso EN en_US
dc.publisher Psychology en_US
dc.title Examining The Effects Of Early Life Stress From Maternal Separation On Measures Of Pain And Anxiety en_US
dc.type M.S. en_US
dc.contributor.committeeChair Fuchs, Perry en_US
dc.degree.department Psychology en_US
dc.degree.discipline Psychology en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US
dc.identifier.externalLink http://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=16
dc.identifier.externalLinkDescription Link to Research Profiles

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