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Visible To Near Infra Red Hyperspectral Imaging: Visualizing The Neurological And Biological Nature Of Ischemic Tissue

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Visible To Near Infra Red Hyperspectral Imaging: Visualizing The Neurological And Biological Nature Of Ischemic Tissue

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dc.contributor.author Suresh, Swetha en_US
dc.date.accessioned 2009-09-16T18:20:28Z
dc.date.available 2009-09-16T18:20:28Z
dc.date.issued 2009-09-16T18:20:28Z
dc.date.submitted January 2008 en_US
dc.identifier.other DISS-10128 en_US
dc.identifier.uri http://hdl.handle.net/10106/1865
dc.description.abstract ABSTRACT VISIBLE TO NEAR INFRARED HYPERSPECTRAL IMAGING VISUALIZING THE NEUROLOGICAL AND BIOCHEMICAL NATURE OF ISCHEMIC TISSUE Swetha Suresh M.S. The University of Texas at ArlingtonSupervising Professor: Dr. Karel J. ZuzakDiabetic Neuropathy is a neuropathic disorder which is associated with Diabetes Mellitus. It is known to result in lower limb ulcers which can lead to amputation. Nerve damage, microvascular dysfunctions and use of ill fitting shoes are significant causes for it. These abnormal dysfunctions can lead to Ischemia. We have used the Multimodal Hyperspectral Imaging System image areas of high pressure on the skin that correspond to pain and also to visualize vascular changes that are associated with this pain. The instrument majorly consists of near-infrared and visible charge coupled devices (CCDs), lenses, liquid crystal tunable filters (LCTFs) for both the CCDs attached to their respective lenses, and a broad band light source. Twenty healthy human subjects had their foot imaged. First, the baseline measure was taken and then an occlusion was introduced with wearing tight shoes to induce temporary Ischemia and removing the shoe resulted in Reactive Hyperemia. After removing the tight shoe the measure of hemoglobin oxygen and carbon dioxide saturation in the area reported as feeling uncomfortable was significantly different from the measure taken from the same area before the tight shoes were worn (Pval < 0.0001).Chemometric analysis produces a gray scale encoded image for the percentage of oxyhemoglobin and carboxyhemoglobin at each pixel within the field of view. Once the shoe is removed, in the microvasculature there will be an increase in the hemoglobin oxygenation saturation and a decrease in the carboxyhemoglobin and a increase of oxyhemoglobin in the macrovasculature of the skin. This study establishes that reactive hyperemia occurs 3-4 minutes after removing the tight shoe and shows that Multimodal Reflectance Hyperspectral Imaging System is a robust imaging method for monitoring vascular changes in the diabetic foot. en_US
dc.description.sponsorship Zuzak, Karel en_US
dc.language.iso EN en_US
dc.publisher Biomedical Engineering en_US
dc.title Visible To Near Infra Red Hyperspectral Imaging: Visualizing The Neurological And Biological Nature Of Ischemic Tissue en_US
dc.type M.S. en_US
dc.contributor.committeeChair Zuzak, Karel en_US
dc.degree.department Biomedical Engineering en_US
dc.degree.discipline Biomedical Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level masters en_US
dc.degree.name M.S. en_US
dc.identifier.externalLink http://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=61
dc.identifier.externalLinkDescription Link to Research Profiles

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