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Synthesis And Evaluation Of Bioceramics For Orthopedics And Tissue Culture Applications

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Synthesis And Evaluation Of Bioceramics For Orthopedics And Tissue Culture Applications

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dc.contributor.author Demirkiran, Hande en_US
dc.date.accessioned 2009-09-16T18:17:00Z
dc.date.available 2009-09-16T18:17:00Z
dc.date.issued 2009-09-16T18:17:00Z
dc.date.submitted January 2009 en_US
dc.identifier.other DISS-10227 en_US
dc.identifier.uri http://hdl.handle.net/10106/1677
dc.description.abstract Hydroxyapatite is the most well known phosphate in the biologically active phosphate ceramic family by virtue of its similarity to natural bone mineral. Among all bioglass compositions Bioglass®45S5 is one of the most bioactive glasses. This study initially started by adding different amounts (1, 2.5, 5, 10, and 25 wt. %) of Bioglass®45S5 to synthetic hydroxyapatite in order to improve the bioactivity of these bioceramics.The chemistries formed by sintering and their effect on different material properties including bioactivity were identified by using various techniques, such as powder and thin film x-ray diffraction, scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, X-ray absorption near edge spectroscopy, compression test, and nano indentation. All the results demonstrated that 10 and 25 wt. % Bioglass®45S5 addition to hydroxyapatite and sintering at 1200ºC for 4 hours yield new compositions with main Ca5(PO4)2SiO4 and Na3Ca6(PO4)5 crystalline phases dispersed in silicate glassy matrices, respectively. In addition, in vitro bioactivity tests such as bone like apatite formation in simulated body fluid and bone marrow stromal cell culture have shown that the crystalline and amorphous phases have an important role on improving bioactivity of these bioceramic compositions. Besides, compression test and nano indentation has given important information on compression strength and nano structure properties of these newly composed bioceramic materials and the bone like apatite layers formed on them, respectively. Finally, the effect of silicate addition on both formation and bioactivity of Na3Ca6(PO4)5 bioceramics were shown. These findings and different techniques used assisted to develop a phenomenological approach to demonstrate how the novel bioceramic compositions were composed and aid improving bioactivity of known bioceramic materials. en_US
dc.description.sponsorship Aswath, Pranesh en_US
dc.language.iso EN en_US
dc.publisher Materials Science & Engineering en_US
dc.title Synthesis And Evaluation Of Bioceramics For Orthopedics And Tissue Culture Applications en_US
dc.type Ph.D. en_US
dc.contributor.committeeChair Aswath, Pranesh en_US
dc.degree.department Materials Science & Engineering en_US
dc.degree.discipline Materials Science & Engineering en_US
dc.degree.grantor University of Texas at Arlington en_US
dc.degree.level doctoral en_US
dc.degree.name Ph.D. en_US
dc.identifier.externalLink http://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=5
dc.identifier.externalLinkDescription Link to Research Profiles

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