Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy

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Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy

Show simple item record Rahimi, Maham en_US 2008-09-17T23:34:56Z 2008-09-17T23:34:56Z 2008-09-17T23:34:56Z June 2008 en_US
dc.identifier.other DISS-2136 en_US
dc.description.abstract Magnetic nanoparticles (MNPs) have been attracting a great amount of attention because of their numerous applications including contrast agents in magnetic resonance imaging (MRI), magnetic targeted drug carriers, and hyperthermia treatments for cancer. However, complications, including aggregation of MNPs, have limited their use in drug delivery applications. To overcome these limitations, several methods have been developed to coat magnetic particles. One method includes coating them with polymers to produce polymer/MNPs for increasing the MNP dispersion and stability. This method also increases the efficiency of loading and releasing drugs to specific locations for the treatment of various diseases including prostate cancer. The major objective of this research project was to develop polymer magnetic nanoparticles (PMNPs) using a silane coupling agent and a novel thermo-sensitive polymer, N-isopropylacrylamide-acrylamide-allylamine (NIPA-AAm-AH). The temperature-sensitive polymers were chosen as a shell for the purpose of creating a controlled drug delivery system. In this system, the temperature induced by the magnetic core would be used to release therapeutic agents from the polymer shell at a specific location. The chemical and physical properties of these PMNPs were determined using Fourier transformed infrared spectroscopy, nuclear magnetic resonance, x-ray photoelectron spectroscopy, and a superconducting quantum interference device. Transmission electron microscopy indicated the size of our PMNPs were about 100 nm. These nanoparticles had a better biocompatibility in comparison to the original MNPs using cytotoxicity assays (e.g. MTS assays). Moreover, bovine serum albumin (BSA) and doxorubicin release profiles from the nanoparticles indicated that our PMNPs released drugs in response to changes in temperature. Finally, results from iron assays and parallel flow chamber systems, with external magnets used to assess the cellular uptake and in vitro localization of the synthesized nanoparticles, indicated that these nanoparticles would provide a means for magnet targeting capabilities. en_US
dc.description.sponsorship Nguyen, Kytai en_US
dc.language.iso EN en_US
dc.publisher Biomedical Engineering en_US
dc.title Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy en_US
dc.type Ph.D. en_US
dc.contributor.committeeChair Nguyen, Kytai en_US Biomedical Engineering en_US Biomedical Engineering en_US University of Texas at Arlington en_US doctoral en_US Ph.D. en_US
dc.identifier.externalLinkDescription Link to Research Profiles

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