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Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity?

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Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity?

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Title: Hypothalamic-Pituitary-Adrenocortical Axis Dysregulation in Acute Temporomandibular Disorder and Low Back Pain: A Marker for Chronicity?
Author: Gatchel, Robert J.; Garofalo, John P.; Robinson, Richard C.
Abstract: Dysregulation of the hypothalamic–pituitary–adrenocortical (HPA) axis is believed to be a valid biological marker of stress. This study evaluating changes in patients with temporomandibular disorders (TMD) and low back pain (LBP) to determine whether dysregulation of this system represents a marker for chronicity. Salivary cortisol samples were collected from 78 patients (TMD = 41, LBP = 37) upon waking up and 20 minutes later daily for 2 weeks. High-risk patients for chronic pain had different overall cortisol levels versus lowrisk patients. High-risk patients exhibited greater variability in terms of cortisol secretion compared with low-risk patients, F (1, 1,243) = 17.73, p < .000. These results provide evidence of a neuroendocrine mechanism underlying a constellation of psychosocial risk factors for chronic pain.
Description: Author's final draft after peer review, also known as a post print.
URI: http://hdl.handle.net/10106/5011
Date: 2006-07
External Link: http://dx.doi.org/10.1111/j.1751-9861.2007.00003.x

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